Glossary entry (derived from question below)
English term or phrase:
calcium linked to receptor-PG synthesis coupling
Russian translation:
см.
Added to glossary by
Julia Berezina
Apr 9, 2021 08:33
3 yrs ago
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English term
12+ years of experience
Native in: Russian 
Works in: Russian to English, English to Russian
calcium linked to receptor-PG synthesis coupling
English to Russian
Medical
Medical: Pharmaceuticals
Pharmacology Written Summ
Benzydamine was a very weak inhibitor of spontaneous PGI2 and PGE2 synthesis by human and rat gastric mucosa and rat kidney.
In contrast, benzydamine was a potent inhibitor of noradrenaline- and carbachol-stimulated (but not arachidonate- or trauma-stimulated) PGI2 synthesis.
It was concluded a) that benzydamine is unlikely to elicit cyclooxygenase-mediated side effects on the gastrointestinal tract or kidney, b) that the anti-inflammatory action of benzydamine is mediated by disruption of calcium linked to receptor-PG synthesis coupling and c) that calcium-dependent inflammatory processes may also be affected by benzydamine.
In contrast, benzydamine was a potent inhibitor of noradrenaline- and carbachol-stimulated (but not arachidonate- or trauma-stimulated) PGI2 synthesis.
It was concluded a) that benzydamine is unlikely to elicit cyclooxygenase-mediated side effects on the gastrointestinal tract or kidney, b) that the anti-inflammatory action of benzydamine is mediated by disruption of calcium linked to receptor-PG synthesis coupling and c) that calcium-dependent inflammatory processes may also be affected by benzydamine.
Proposed translations
(Russian)
| 3 | см. |
Igor Andreev
|
Proposed translations
3 hrs
Igor Andreev
Native in Russian
Native in: Russian
Works in: English to Russian, Ukrainian to Russian, English to Ukrainian
Related KudoZ points
:
625
Selected
см.
disruption of calcium linked to receptor-PG synthesis coupling - нарушение Ca-зависимого механизма индукции синтеза простагландинов при активации рецепторов
(букв. кальций, связанный с сопряжением [активации] рецепторов и синтеза простагландинов)
возможно получится сформулировать изящнее, но общий смысл таков
См. цитаты из первоисточника фразы
Both noradrenaline- and carbachol-stimulated PG synthesis in these tissues is linked to the mobilization of calcium (which in turn activates PLA2 which liberates AA from endogenous stores) whereas trauma and arachidonate stimulate PG synthesis by bypassing this intrinsic receptor-linked calcium-mobilization step [12]. Thus, it is possible that benzydamine, as with other NSAIDs, inhibits the mobilization of calcium stores linked to PLA2 activation. This conclusion is also in general agreement with Loftier et al. [24] who demonstrated that benzydamine inhibited the release of fatty acids from phospholipids at concentrations similar to those found to inhibit agonist-stimulated PG synthesis in this study.
...
The anti-inflammatory action of benzydamine is probably not due to inhibition of cyclooxygenase but possibly to disruption of calcium mobilization/sequestration linked to PG synthesis at the plasma membrane of inflammatory cells. Furthermore, since calcium is a universal second messenger, benzydamine may inhibit other calcium-dependent pro-inflammatory events (e.g. histamine release from mast cells).
https://link.springer.com/article/10.1007/BF02735396
(букв. кальций, связанный с сопряжением [активации] рецепторов и синтеза простагландинов)
возможно получится сформулировать изящнее, но общий смысл таков
См. цитаты из первоисточника фразы
Both noradrenaline- and carbachol-stimulated PG synthesis in these tissues is linked to the mobilization of calcium (which in turn activates PLA2 which liberates AA from endogenous stores) whereas trauma and arachidonate stimulate PG synthesis by bypassing this intrinsic receptor-linked calcium-mobilization step [12]. Thus, it is possible that benzydamine, as with other NSAIDs, inhibits the mobilization of calcium stores linked to PLA2 activation. This conclusion is also in general agreement with Loftier et al. [24] who demonstrated that benzydamine inhibited the release of fatty acids from phospholipids at concentrations similar to those found to inhibit agonist-stimulated PG synthesis in this study.
...
The anti-inflammatory action of benzydamine is probably not due to inhibition of cyclooxygenase but possibly to disruption of calcium mobilization/sequestration linked to PG synthesis at the plasma membrane of inflammatory cells. Furthermore, since calcium is a universal second messenger, benzydamine may inhibit other calcium-dependent pro-inflammatory events (e.g. histamine release from mast cells).
https://link.springer.com/article/10.1007/BF02735396
4 KudoZ points awarded for this answer.
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