Glossary entry (derived from question below)
Italian term or phrase:
cloro glutammato-dipendente
English translation:
glutamate-dependent (gated) chloride channels
Added to glossary by
Susan Gastaldi
Jan 8, 2009 18:15
15 yrs ago
2 viewers *
Italian term
Totally reliable, top quality
Native in: English 
Works in: Italian to English, French to English
cloro glutammato-dipendente
Italian to English
Medical
Medical: Pharmaceuticals
description of a product for dogs
glutammate-dependent chloride ions, or chlorine ions? I'm never sure... Thanks for any suggestions
"I composti di questa classe si legano selettivamente ai canali ionici del cloro glutammato-dipendenti delle cellule nervose e muscolari degli invertebrati"
"I composti di questa classe si legano selettivamente ai canali ionici del cloro glutammato-dipendenti delle cellule nervose e muscolari degli invertebrati"
Proposed translations
(English)
| 5 +2 | glutamate-dependent (gated) chloride channels |
Lionel_M (X)
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| 5 +2 | chloride ions |
Zareh Darakjian Ph.D.
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| 4 | glutammate-dependent chlorine ion channels |
Giuliana Mafrica
|
Proposed translations
+2
35 mins
Selected
glutamate-dependent (gated) chloride channels
http://www.springerlink.com/content/k2p1k047m4277211/
gated or dependent is the same ! As a matter of fact, both gated and dependent are used in this paper
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Note added at 38 mins (2009-01-08 18:54:19 GMT)
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(WO/2008/034202) USE OF IVERMECTIN AND DERIVATES THEREOF FOR THE ... - [ Traduci questa pagina ]Its binding to glutamate-dependent chloride channels promotes an ... But several other ligand- gated ion channels are activated and/or modulated by IVM. ...
www.wipo.int/pctdb/en/wo.jsp?wo=2008034202&IA=BE2007000107&... - 79k - Copia cache - Pagine simili
gated or dependent is the same ! As a matter of fact, both gated and dependent are used in this paper
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Note added at 38 mins (2009-01-08 18:54:19 GMT)
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(WO/2008/034202) USE OF IVERMECTIN AND DERIVATES THEREOF FOR THE ... - [ Traduci questa pagina ]Its binding to glutamate-dependent chloride channels promotes an ... But several other ligand- gated ion channels are activated and/or modulated by IVM. ...
www.wipo.int/pctdb/en/wo.jsp?wo=2008034202&IA=BE2007000107&... - 79k - Copia cache - Pagine simili
Peer comment(s):
| agree |
ARS54
: con glutamate-gated... REPLY: OK, but may I say it sounds better to me? (non so fare la faccina col sorriso, cmq. è come se ci fosse!). Ciao! R.R.: ...Lionel, I was only jocking about it, I gave you my "agree"!! (Faccina smile)
1 hr
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As I pointed out with scientific papers, "gated" or "dependent" does not change the meaning. Thank you ARS !//OK ARS. let's put "gated" if it "sounds"...since for scientists it does not make difference-))//RR Yes I know ARS; I appreciate -)) Thks
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| agree |
Lirka
: correct
16 hrs
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Thks Lirka
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4 KudoZ points awarded for this answer.
Comment: "Thank you, Lionel, and thanks to all"
9 mins
Giuliana Mafrica
Italy
Italy
Native in Italian
Specializes in field
Italy
Medical-pharma&IT translator since 1996
Native in: Italian
Works in: English to Italian, German to Italian, Italian to English
Related KudoZ points
:
4
glutammate-dependent chlorine ion channels
cloro: chlorine. Cloruro: chloride
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Note added at 19 min (2009-01-08 18:34:52 GMT)
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There are many occurrencies of the definition "chlorine ion channels", as for example the Wikipedia page http://en.wikipedia.org/wiki/End-plate_potential, which states: "The polarization of membranes is controlled by sodium, potassium, calcium, and chlorine ion channels."
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Note added at 19 min (2009-01-08 18:34:52 GMT)
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There are many occurrencies of the definition "chlorine ion channels", as for example the Wikipedia page http://en.wikipedia.org/wiki/End-plate_potential, which states: "The polarization of membranes is controlled by sodium, potassium, calcium, and chlorine ion channels."
Peer comment(s):
| neutral |
Zareh Darakjian Ph.D.
: I failed to look at the context.. However, it should be "chloride ion" and not chlorine. Also, it's not dependent. It is "gated".
3 mins
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| neutral |
Lionel_M (X)
: I agree, but it's GLUTAMATE and CHLORIDE (ion is not necessary for scientific paper; of course it's an "ion")
5 hrs
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| neutral |
Lirka
: chloride
16 hrs
|
+2
10 mins
Zareh Darakjian Ph.D.
United States
United States
Native in English
Specializes in field
United States
A scientist, pianist and a translator
Native in: English 
, Armenian
Works in: German to English, French to English, Spanish to English, and 2 more.
Related KudoZ points
:
48
chloride ions
The ions are charged. Cl^-. Even though it might sound redundant (chloride implies negative ions), still, that's the correct
way of saying it: chloride ions. Only with positive ions do we give the name of the element: (e.g. potassium ions). In the negative ion case, the the ine changes to ide (or other times, ate, ite, etc.), but still we should say "chloride ions" and not chlorine ions.
Furthermore, there are, in very rare cases, chlorine e(positive) isons as well as in ClO. (charge on Cl here is +2).
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Note added at 15 mins (2009-01-08 18:31:02 GMT)
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I did not answer the term as posted.. I answered your question regarding chloride versus chlorine... but yes, as Giuliana has (with chloride instead of chlorine) it is:
chloride-ion dependent channels.
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Note added at 17 mins (2009-01-08 18:33:31 GMT)
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Actually, dependent is not standard. It is:
glutamate-gated chloride ion channesl. Many Google hits, if you wish to consider those. Among other things, I teach physiology tp undergraduate and pre-med students.
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Note added at 19 mins (2009-01-08 18:35:34 GMT)
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http://www.ionchannels.org/showabstract.php?pmid=10820028
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Note added at 21 mins (2009-01-08 18:37:19 GMT)
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Abstract Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods. However, ivermectin and other avermectins very often produce side-effects in hosts. The most dominant clinical symptom of ivermectin toxicity in domestic and wild animals is CNS depression. In nematodes, the target site of ivermectin’s action is **glutamate-gated chloride-channel** receptor and GABA receptor.
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Note added at 23 mins (2009-01-08 18:38:48 GMT)
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http://journals.cambridge.org/action/displayAbstract?fromPag...
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Note added at 25 mins (2009-01-08 18:41:26 GMT)
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**Glutamate-gated chloride channel** with glutamate-transporter-like properties in cone photoreceptors of the tiger salamander
S. A. Picaud, H. P. Larsson, G. B. Grant, H. Lecar and F. S. Werblin
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
******
You may also delete "chloride" entirely, and say:
** glutamtate-dependent cholride channels **.
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Note added at 26 mins (2009-01-08 18:42:01 GMT)
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Sorry, that should be:
*** glutamtate-gated chloride channels ***
way of saying it: chloride ions. Only with positive ions do we give the name of the element: (e.g. potassium ions). In the negative ion case, the the ine changes to ide (or other times, ate, ite, etc.), but still we should say "chloride ions" and not chlorine ions.
Furthermore, there are, in very rare cases, chlorine e(positive) isons as well as in ClO. (charge on Cl here is +2).
--------------------------------------------------
Note added at 15 mins (2009-01-08 18:31:02 GMT)
--------------------------------------------------
I did not answer the term as posted.. I answered your question regarding chloride versus chlorine... but yes, as Giuliana has (with chloride instead of chlorine) it is:
chloride-ion dependent channels.
--------------------------------------------------
Note added at 17 mins (2009-01-08 18:33:31 GMT)
--------------------------------------------------
Actually, dependent is not standard. It is:
glutamate-gated chloride ion channesl. Many Google hits, if you wish to consider those. Among other things, I teach physiology tp undergraduate and pre-med students.
--------------------------------------------------
Note added at 19 mins (2009-01-08 18:35:34 GMT)
--------------------------------------------------
http://www.ionchannels.org/showabstract.php?pmid=10820028
--------------------------------------------------
Note added at 21 mins (2009-01-08 18:37:19 GMT)
--------------------------------------------------
Abstract Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods. However, ivermectin and other avermectins very often produce side-effects in hosts. The most dominant clinical symptom of ivermectin toxicity in domestic and wild animals is CNS depression. In nematodes, the target site of ivermectin’s action is **glutamate-gated chloride-channel** receptor and GABA receptor.
--------------------------------------------------
Note added at 23 mins (2009-01-08 18:38:48 GMT)
--------------------------------------------------
http://journals.cambridge.org/action/displayAbstract?fromPag...
--------------------------------------------------
Note added at 25 mins (2009-01-08 18:41:26 GMT)
--------------------------------------------------
**Glutamate-gated chloride channel** with glutamate-transporter-like properties in cone photoreceptors of the tiger salamander
S. A. Picaud, H. P. Larsson, G. B. Grant, H. Lecar and F. S. Werblin
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
******
You may also delete "chloride" entirely, and say:
** glutamtate-dependent cholride channels **.
--------------------------------------------------
Note added at 26 mins (2009-01-08 18:42:01 GMT)
--------------------------------------------------
Sorry, that should be:
*** glutamtate-gated chloride channels ***
Peer comment(s):
| neutral |
Lionel_M (X)
: Common Zareh ! On a pharmacological point of view, “gating” has nothing to do with “polarization !” Anyway, you proposed the same I did, so we agree !!! Thanks
29 mins
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Thank you, Lionel. I did misspell "glutamate"! On the other hand, "dependent" and gated are very different. "Dependent" is appropriate for say ATP-dependent (energy requirement). "Gating" secures the requisite polarization sign and magnitude.
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| agree |
ARS54
: ...con l'ultima nota
1 hr
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Thank you, ARSS4.
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| agree |
luskie
: anch'io
1 hr
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Thank you,luskie.
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| neutral |
Lirka
: what about channels??
16 hrs
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You are right. I addded it later...
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Discussion
glutamate-dependent chloride channels. You may Google and see...
For the "scientific" precisiom I agree with Zareh: "gated" is more appropriate and more "elegant" for an ion
Lionel, re spelling, I apologise for my typo in English - of course glutamate only has one 'm', but glutammato appears to have two, at least in my original document.