See:

http://en.wikipedia.org/wiki/Nuclear_poison

During operation of a reactor the amount of fuel contained in the core constantly decreases. If the reactor is to operate for a long period of time, fuel in excess of that needed for exact criticality must be added when the reactor is built. The positive reactivity due to the excess fuel must be balanced with negative reactivity from neutron-absorbing material. Movable control rods containing neutron-absorbing material is one method, but control rods alone to balance the excess reactivity may be impractical for a particular core design as there may be insufficient room for the rods or their mechanisms.